Phenytoin sketchy

Phenytoin (PHT), sold under the brand name Dilantin among others, is an anti-seizure medication. It is useful for the prevention of tonic-clonic seizures (also known as grand mal seizures) and focal seizures, but not absence seizures. The intravenous form, fosphenytoin, is used for status epilepticus that does not improve with benzodiazepines. It may also be …

Phenytoin sketchy. As phenytoin or phenytoin Na: Initially, 3-4 mg/kg daily or 150-300 mg daily given as a single dose or in divided doses, may gradually increase up to 600 mg daily at a minimum interval of 7-10 days if necessary. Maintenance: 200-500 mg daily as a single dose or in divided doses. Dosage must be individualised and adjusted according to clinical ...

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Learn how to protect your home from wildfires with our comprehensive guide to firescaping. Get tips and resources for creating a fire-resistant landscape. Expert Advice On Improvin...Carbamazepine is used to manage and treat epilepsy, trigeminal neuralgia, and acute manic and mixed episodes in bipolar I disorder. Indications for epilepsy are specifically for partial seizures with complex symptomatology (psychomotor, temporal lobe), generalized tonic seizures (grand mal), and mixed seizure patterns. This activity will highlight off-label uses, mechanism of action, dosing ...Phenytoin is a highly effective anticonvulsant medication that is considered to be the treatment of choice for generalized major motor and focal epileptic seizures. An …On the other hand, levetiracetam can lead to agitation in some patients. Pregnancy is a critical factor when prescribing AEDs, as certain antiepileptics, such as valproic acid and phenytoin, are known teratogens. Notably, phenytoin is a Na channel blocker and P450 inducer, associated with complications like cardiac arrhythmias and SJS/TENS.Sketchy Pharm: Ganciclovir, Valganciclovir, Foscarnet, And Cidofovir. Sketchy Micro: Gardneralla Vaginalis. Pathoma: Ovary. Sketchy Micro: Trichomoniasis. Sketchy Micro: Retrovirus Hiv/Aids. Study Sketchy Pharm: Aminoglycosides flashcards from Billy Tran's class online, or in Brainscape's iPhone or Android app. Learn faster …Study this MAOIs mnemonic and other NCLEX mnemonics with Pixorize.MAOIs are a class of antidepressants and include the drugs isocarboxazid, phenelzine, and t...Phenytoin is one of the most widely prescribed antiepileptic drugs (AEDs) in the USA (approximately 52% of AED prescriptions compared with 19% for valproic acid, 11% carbamazepine, and 7% phenobarbital) [ 1 ]. It has a narrow therapeutic range and wide interindividual variability in clearance and, as such, therapeutic drug monitoring is often ...Dilantin. Drug Class. Anticonvulsant. Pregnancy Category. Category C. Usage. To treat tonic-clonic, simple, or complex partial seizures in patients who have had no prior treatment. Dosage: Adults. Initial: 125 mg suspension or 100 to 125 mg tablet t.i.d., adjusted every 7 to 10 days as needed and tolerated.

Phenytoin is an antiepileptic drug which can be used in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or …cimetidine may prolong or potentiate actions of:-warfarin -benzo's-phenytoin -propranolol-theophylline -nifedepine-phenobarbital -digoxin-quinidine -tricyclic antidepressantsphenytoin: [noun] a crystalline anticonvulsant compound C15H12N2O2 used in the form of its sodium salt in the treatment of epilepsy — called also#R##N# diphenylhydantoin.Eco-anxiety is a chronic concern over environmental issues. Learn about eco-anxiety a treatments for eco-anxiety. Advertisement ­Do ­you burst into tears at the mere mention of the...We would like to show you a description here but the site won’t allow us.Tricyclic antidepressants (TCAs) constitute a class of medications used to manage and treat major depressive disorder (MDD). These medications function by inhibiting the reuptake of neurotransmitters, such as serotonin and norepinephrine, which can modulate mood, attention, and pain in individuals. The U.S. Food and Drug …

Phenytoin (PHT), sold under the brand name Dilantin among others, is an anti-seizure medication. It is useful for the prevention of tonic-clonic seizures (also known as grand mal seizures) and focal seizures, but not absence seizures. The intravenous form, fosphenytoin, is used for status epilepticus that does not improve with benzodiazepines. It may also be …A chill has descended onto the global startup market, albeit not evenly. Venture capital totals are sagging in most geographies, and falling share prices for tech companies large a...Sketchy Pharmacy currently includes 11 courses key to mastering your Pharmacy studies, including: Pharmacology, Pharmacokinetics, Biostatistics & Epidemiology, Compounding & Calculations, Pathophysiology, Microbiology, Biochemistry, Diagnosis & Management, Obstetrics & Gynecology, Pediatrics, and Disease Prevention. The Sketchy Pharmacy …Phenytoin is used to prevent and control seizures (also called an anticonvulsant or antiepileptic drug). It works by reducing the spread of seizure activity in the brain. Phenytoin may also be used to treat certain types of irregular heartbeats. Phenytoin is available under the following different brand names: Dilantin, Dilantin 125, and Phenytek.Eco-anxiety is a chronic concern over environmental issues. Learn about eco-anxiety a treatments for eco-anxiety. Advertisement ­Do ­you burst into tears at the mere mention of the...

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We would like to show you a description here but the site won’t allow us.Long story short, I couldn't fully incorporate sketchy into my studies. Now it seems of no use to me. I would like to sell the 5 months subscription on a slightly discounted price of $60. Being an IMG, it was kind of a big decision getting it as it is not exactly cheap. Anyone interested in buying it, please DM me.Sketchy Pharmacy is the perfect companion for any pharmacy student to manage their busy study schedule and make studying more fun in pharmacy school. Sketchy Team Sep 1, 2022 Join the Sketchy Family. Subscribe to our mailing list and get exclusive studying tips, connect with our community, get first dibs on special offers and content updates. ...Inhibit protein synthesis by blocking translocation ("macroslides"); bind to the 23S rRNA of the 50S ribosomal subunit. Blocks peptide transfer (translocation) at 50S ribosomal subunit. Bacteriostatic. Study with Quizlet and memorize flashcards containing terms like , Inhibitors of Bacterial Protein Synthesis, Tetracycline MOA and more.

General Properties of Anticonvulsants. Antiepileptic drugs (AED) can be separated by mechanism of action (MOA) affecting voltage-gated Na+ channels. affecting Ca2+ channels. affecting GABA activity. Choice of AED is dependent on seizure type, patient, and side-effect profile. Affecting Voltage-Gated Na+ Channels.We would like to show you a description here but the site won’t allow us.phenytoin: [noun] a crystalline anticonvulsant compound C15H12N2O2 used in the form of its sodium salt in the treatment of epilepsy &mdash; called also#R##N# diphenylhydantoin.Phenytoin is a medication used to treat epilepsy (seizure disorder). If phenytoin is taken by the mother in the first trimester, there is approximately a 5 to 10 percent chance that the baby could be born with a combination of birth defects known as the Fetal Hydantoin Syndrome. Babies with this syndrome may be born with some of the following ...Sketchy Pharm: Ganciclovir, Valganciclovir, Foscarnet, And Cidofovir. Sketchy Micro: Gardneralla Vaginalis. Pathoma: Ovary. Sketchy Micro: Trichomoniasis. Sketchy Micro: Retrovirus Hiv/Aids. Study Sketchy Pharm: Beta Blockers flashcards from Billy Tran&#39;s class online, or in Brainscape&#39;s iPhone or Android app. Learn faster …Study with Quizlet and memorize flashcards containing terms like Phenytoin (trade), Phenytoin (sketchy association), Phenytoin (action) and more.After a study of 527 subarachnoid hemorrhage patients, the authors concluded that higher quartiles of phenytoin burden were associated with worse telephone interviews for cognitive status scores at hospital discharge (P<0.001) and at 3 months (P=0.003) as well as poor functional outcome at 14 days (P<0.001) but not at 3 months (P=0.09). The ...CLINICAL PHARMACOLOGY. Phenytoin is an antiepileptic drug which can be used in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by …Phenytoin is used to prevent and control seizures (also called an anticonvulsant or antiepileptic drug). It works by reducing the spread of seizure activity in the brain. Phenytoin may also be used to treat certain types of irregular heartbeats. Phenytoin is available under the following different brand names: Dilantin, Dilantin 125, and Phenytek.Melatonin acts through MT1 and MT2 receptors to suppress firing of SCN neurons, thereby disinhibiting the sleep-promoting neurons in the VLPO. Melatonin also suppresses excitatory signals from SCN to lateral HTH which secretes orexin (hypocretin) which acts on OX1 and OX2 receptors to activate monoamine arousal systems.liver problems - loss of appetite, upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Common phenytoin side effects may include: problems with balance, coordination, or muscle movement. This is not a complete list of side effects and others may occur.

Phenytoin side effects. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).. Seek medical treatment if you have a …

Sketchy Pharm. Valproic acid. Click the card to flip 👆. -Broad-spectrum anticonvulsant; inactivates Na+ channels & increases GABA. -Uses: generalized seizures (including JME) -AEs: N/V, weight gain, tremor, hepatitis /pancreatitis, teratogenic. -Inhibits CYP450.After a study of 527 subarachnoid hemorrhage patients, the authors concluded that higher quartiles of phenytoin burden were associated with worse telephone interviews for cognitive status scores at hospital discharge (P<0.001) and at 3 months (P=0.003) as well as poor functional outcome at 14 days (P<0.001) but not at 3 months (P=0.09). The ...Phenytoin. This aromatic AED has been available in the UK to treat focal onset seizures and status for over 60 years. It is also licensed for postsurgical/post head injury seizure prophylaxis. Cutaneous reactions seen in 5% of patients limit its use. The incidence of SJS/TEN is reported 69/100,000, and 23/100,000 for DRESS.Pixorize makes visual mnemonics covering biochemistry, immunology, pharmacology, and more for the USMLE, NCLEX, and MCAT exams. Our videos are simple and mem... We would like to show you a description here but the site won’t allow us. Phenytoin is indicated to treat grand mal seizures, complex partial seizures, and to prevent and treat seizures during or following neurosurgery. 14 Injectable phenytoin and …Watch a free lesson about Megaloblastic Anemia: Folate Deficiency & Vitamin B12 Deficiency from our Blood & Coagulation unit. Sketchy Medical helps you ...Apr 14, 2021 · Phenytoin is a prescription drug. It comes in three oral forms: extended-release capsule, chewable tablet, and suspension. It also comes as an injectable medication that’s given by a healthcare ... Contributors. Filip Vasiljević, MD, Jerry Ferro, Jennifer Montague, PhD, Talia Ingram, MSMI, CMI. Antiepileptics, also known as anticonvulsants, are medications primarily used to treat epilepsy, as well as generalized or …

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Nonbenzodiazepine anticonvulsants are a class of drugs used to treat seizures, headaches, and neuropathic pain. These drugs are also used as mood stabilizers for bipolar disorders. Nonbenzodiazepine …Phenytoin Dosing Calculator. This initial program provides some general dosage guidelines based on population averages for the Michaelis-Menten parameters (Km and Vmax). The recommendations do not take into account the following: (1) existence of interacting drugs (3) inter-patient variability (3) existing disease states which may significantly ...Watch a free lesson about Carbamazepine, oxcarbazepine, phenytoin, tiagabine, vigabatrin from our Neuro/Psych unit. Sketchy Medical helps you learn faster and score …Tradable credits for nature conservation bypass some of the sketchy math of carbon offsets The projections for life on earth are bleak: At the current rate, one million known speci...Sketchy Preclinical Checklist microbiology pharmacology pathology biochemistry 2021 sketchy micro bacteria chapter gram positive cocci staphylococcus aureus ... lamotrigine, levetiracetam 4 - Carbamazepine, phenytoin, gabapentin, tiagabine, vigabatrin 4 – Ethosuximide. SKETCHY PHARM. CHAPTER 5 ANTIFUNGALS 5 - Amphotericin, …Phenytoin/Phenobarb Smoking Phenytoin/Phenobarb Oxycarbazepine Rifampin Carbamazepine St. John's Wort G <3 PACMAN = Inhibitors. Grapefruit PI (esp. rotonivir) Azole antifungals Cimetidine Macrolides Amiodarone Non-DHP CCB's Yes, Phenytoin/phenobarb repeat but it still works pretty well. Anti-Seizure Drugs (with sketchy pictures) 50%, 15%. Click the card to flip 👆. about ___ of people respond to first medication, ___ to the second, and the rest are generally unresponsive to medication. Click the card to flip 👆. 1 / 52. Study this ACE Inhibitors NCLEX mnemonic and other mnemonics with Pixorize.ACE Inhibitors (ACEIs) are medications that end in -pril, including lisinopril, ca...Study this Benzodiazepines mnemonic for NCLEX and other mnemonics with Pixorize.Benzodiazepines, or benzos for short, are a large class of drugs with drug na...Phenytoin is one of the most widely prescribed antiepileptic drugs (AEDs) in the USA (approximately 52% of AED prescriptions compared with 19% for valproic acid, 11% carbamazepine, and 7% phenobarbital) [ 1 ]. It has a narrow therapeutic range and wide interindividual variability in clearance and, as such, therapeutic drug monitoring is often ...We would like to show you a description here but the site won’t allow us.Phenytoin is a hydantoin compound related to the barbiturates that are used for the treatment of seizures. It is an effective anticonvulsant for the chronic treatment of tonic-clonic (grand mal) or partial seizures and the acute treatment of generalized status epilepticus ( Table 10-1 ). 1, 2 After generalized status epilepticus has been ... ….

Study Sketchy Pharm: Carbamazepine, Phenytoin, Gabapentin, Tiagabine, Vigabatrin flashcards from Billy Tran's class online, or in Brainscape's iPhone or Android app. Learn faster with spaced repetition.2 anti-seizure drugs that can cause osteoporosis. carbamazepine. phenytoin. blood side effect shared by carbamazepine and phenytoin that is not agranulocytosis. megaloblastic anemia. 3 side effects of valproate besides weight gain not mentioned in sketchy. hair loss. thrombocytopenia. polycystic ovaries.Aug 8, 2023 · Since its discovery in 1908, phenytoin has become one of the most well-studied anticonvulsants. With an average monthly cost of $30, it has also become one of the most widely used anticonvulsants, listed on the World Health Organization’s List of Essential Medicines. However, with its narrow therapeutic index and its pervasive daily use, considering potential phenytoin overdose or toxicity ... There are 2 major categories of patients with seizures and chronic kidney disease (CKD): patients who develop acute symptomatic seizures in the setting of CKD and patients with epilepsy who at some point develop CKD. The incidence of uremic seizures with kidney failure is ∼10%. These seizures are often nonconvulsive and may mimic …General Properties of Anticonvulsants. Antiepileptic drugs (AED) can be separated by mechanism of action (MOA) affecting voltage-gated Na+ channels. …Mar 12, 2018 · Fetal hydantoin syndrome is a characteristic pattern of mental and physical birth defects that results from maternal use of the anti-seizure (anticonvulsant) drug phenytoin (Dilantin) during pregnancy. The range and severity of associated abnormalities will vary greatly from one infant to another. fever, chills, sore throat, swollen glands; red or swollen gums, mouth sores; easy bruising, unusual bleeding, purple or red spots under your skin; or. liver problems--loss of appetite, upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Common side effects of Phenytek may include: drowsiness, confusion;Phenytoin is an antiepileptic drug which can be used in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or …Phenytoin is an anticonvulsant that in rare cases can cause acute idiosyncratic drug-induced liver disease that can be severe or even fatal. The liver injury caused by phenytoin appears to be due to a hypersensitivity reaction and resembles cases of immunoallergic hepatotoxicity. This syndrome is more common in African Americans …Bu-phine: buprenorphine, nalbuphine, and butorphanol. Think of the Blue Fin grill with the partial massage (the foot massage) 21. Q. The two mu-opioid antagonists are ____________. A. naloxone (no lax zone –don’t relax) and naltrexone (no tricks zone) Study Sketchy Pharm: Opiates, Naloxone, Naltrexone flashcards from Billy Tran&#39;s class ... Phenytoin sketchy, Phenytoin is an antiepileptic drug which can be used in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or …, Need a change management consulting company in Canada? Read reviews & compare projects by leading change management consultants. Find a company today! Development Most Popular Emer..., Study this Carbamazepine NCLEX mnemonic and other mnemonics with Pixorize.Carbamazepine is a drug most commonly used to treat trigeminal neuralgia, but is al..., Study with Quizlet and memorize flashcards containing terms like Phenytoin, High potency FGAs, Low potency FGAs and more., We would like to show you a description here but the site won’t allow us., Sketchy Preclinical Checklist microbiology pharmacology pathology biochemistry 2021 sketchy micro bacteria chapter gram positive cocci staphylococcus aureus ... lamotrigine, levetiracetam 4 - Carbamazepine, phenytoin, gabapentin, tiagabine, vigabatrin 4 – Ethosuximide. SKETCHY PHARM. CHAPTER 5 ANTIFUNGALS 5 - Amphotericin, …, The power of Sketchy (as told by me) can be found here, but long story short: the mnemonic sketches that I’d watched and studied a year prior stuck with me so strongly that I was able to answer questions even years later. Update (2021): There is no current discount code for Pixorize, unfortunately. The Pixorize team has been very …, Review. Pharmacology. Mechanisms of Action. Phenytoin is an AED that works by binding and stabilizing the inactivated state of sodium channels and blocks the high-frequency firing of neurons and spread of seizure activity [].]. Phenytoin is highly protein-bound and is metabolized by cytochrome P450 (CYP) enzymes, in addition to …, Facebook scammers are impersonating Facebook and spreading malware by buying ads from, you guessed it, Facebook. Sketchy Facebook pages impersonating businesses are nothing new, bu..., Check with your doctor or nurse immediately if any of the following side effects occur: More common. Chest pain or discomfort cold, clammy, or pale skin, Sketchy Pharm: Ganciclovir, Valganciclovir, Foscarnet, And Cidofovir. Sketchy Micro: Gardneralla Vaginalis. Pathoma: Ovary. Sketchy Micro: Trichomoniasis. Sketchy Micro: Retrovirus Hiv/Aids. Study Sketchy Pharm: Aminoglycosides flashcards from Billy Tran&#39;s class online, or in Brainscape&#39;s iPhone or Android app. Learn faster …, Phenytoin Dosing Calculator. This initial program provides some general dosage guidelines based on population averages for the Michaelis-Menten parameters (Km and Vmax). The recommendations do not take into account the following: (1) existence of interacting drugs (3) inter-patient variability (3) existing disease states which may significantly ..., Phenytoin ( PHT ), sold under the brand name Dilantin among others, [1] is an anti-seizure medication. [3] It is useful for the prevention of tonic-clonic seizures (also known as grand mal seizures) and focal seizures, but not absence seizures. [3] The intravenous form, fosphenytoin, is used for status epilepticus that does not improve with ... , The maximum single oral dose should not exceed 400 mg in order to minimize GI side effects and also increase absorption (decrease likelihood of concretions). Sampling: 18 to 24 hours after the loading dose, and then every 5 to 7 days to assess trend. Average time to steady state: 10-14 days., We would like to show you a description here but the site won’t allow us. , Ethosuximide is an anticonvulsant used to treat petit mal seizures. Brand Names. Zarontin. Generic Name. Ethosuximide. DrugBank Accession Number. DB00593. Background. An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures., Try for 7 days free. Plans as low as $15/mo. made to stick. Sketchy for pharmacy school transforms even the trickiest subjects into short, enjoyable lessons that you can easily absorb and remember, all the way through NAPLEX test day. Say goodbye to dry study sessions and hello to Sketchy's entertaining approach to pharmacy school learning with ..., Tradable credits for nature conservation bypass some of the sketchy math of carbon offsets The projections for life on earth are bleak: At the current rate, one million known speci..., The narrow therapeutic index of phenytoin and its ubiquitous daily use pose a high risk of poisoning. This review article focuses on the chemistry, pharmacokinetics, and …, and phenytoin use (details in Supplementary Material). Evidence is summarized in Table S1 and Table S2. Genes: HLA-B and CYP2C9 Background. This guideline discusses and the risk of HLA-B Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with phenytoin and as it relates to phenytoin CYP2C9 metabolism and dosing. , Interactions. Phenytoin is an inducer of the hepatic cytochrome P450 microsomal isoenzymes CYP3A4, CYP2D6, CYP1A2, CYP2C9 and CYP2C19. Phenytoin is metabolised primarily by. CYP2C9 (major) and CYP2C19 (minor), thus several drugs may inhibit or induce the. metabolism of phenytoin., Study Sketchy Pharm: Carbamazepine, Phenytoin, Gabapentin, Tiagabine, Vigabatrin flashcards from Walter The-Cat's class online, or in Brainscape's iPhone or Android app. Learn faster with spaced repetition., SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join My goal is to reduce educational disparities by making education FR..., Commonly associated with CBZ and PHT CFHR4 has an association with Phenytoin induced maculopapular exanthema. HLA-A*3101 has an association with CBZ induced maculopapular exanthema. Most common in children and young adults, and in those with a history of allergy or atopy: HLA-B*22: Rapid titration., Phenytoin is one of the most widely prescribed antiepileptic drugs (AEDs) in the USA (approximately 52% of AED prescriptions compared with 19% for valproic acid, 11% carbamazepine, and 7% phenobarbital) [ 1 ]. It has a narrow therapeutic range and wide interindividual variability in clearance and, as such, therapeutic drug monitoring is often ... , Interactions. Phenytoin is an inducer of the hepatic cytochrome P450 microsomal isoenzymes CYP3A4, CYP2D6, CYP1A2, CYP2C9 and CYP2C19. Phenytoin is metabolised primarily by. CYP2C9 (major) and CYP2C19 (minor), thus several drugs may inhibit or induce the. metabolism of phenytoin., Santa's client lists get bigger every year and managing those lists gets more complicated every Christmas. Your email address will not be published. Required fields are marked * Co..., Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and non-linear pharmacokinetics. However, serum drug levels should only be taken when there is a clear indication to guide patient ..., 👉📖 READY TO ACE YOUR EXAM? 📚 GET STUDY NOTES ON PATREON!https://www.patreon.com/speedpharmacologyAntiepileptic drugs, also referred to as anticonvulsants,..., Phenytoin is a major anticonvulsant drug that is very effective in controlling a wide variety of seizure disorders while impairing neurological function little, if at all. Early work suggested the hypothesis that the drug's effects were due to a selective block of high-frequency neuronal activity. This theory is reevaluated in the light of ..., Phenytoin is a drug that is used to control seizures and it is generally used as an anticonvulsant or antiepileptic drug. The drug is also known by other brand names like Dilantin or Eptoin. It works by slowing down the impulses in the brain and minimizing the activity of brain stem centers. Phenytoin also acts as an anti-arrhythmic and a ..., The power of Sketchy (as told by me) can be found here, but long story short: the mnemonic sketches that I’d watched and studied a year prior stuck with me so strongly that I was able to answer questions even years later. Update (2021): There is no current discount code for Pixorize, unfortunately. The Pixorize team has been very …, Our wildly loved Pharmacology course is now streaming on YouTube! Dive into free previews covering high-yield topics like sympathomimetics, cholinomemetics, ...