Splitting ozempic dose

The normal titration schedule for Wegovy is .25, .50, 1.0,1.7, 2.4 UNLESS you are switching over from Ozempic 1.0. A newbie starting at 1.7 would most likely end up in the hospital with either severe dehydration from the vomiting, or possibly pancreatitis. Everything depends on what you are eating.

Semaglutide injection (Ozempic) is also used to reduce the risk of a stroke, heart attack, or death in adults who have type 2 diabetes along with heart and blood vessel disease. It is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood) or diabetic ...When you take Ozempic, it activates GLP-1 receptors in your body, causing an increase in insulin. That helps treat type 2 diabetes, Dr. Shah says. But while Ozempic is designed to treat type 2 ...Ozempic’s efficacy for weight loss has been widely researched. A recent study found that adults who took a 1 mg dose of Ozempic for a trial period of 40 weeks lost an average of 13 pounds in body weight. People receiving a 2 mg dose lost an average of 15 pounds. Another study discovered that after six weeks of taking the medication ...So I'm taking the 2 mg dose now but I was thinking of splitting it up because I have some minor side effects so could I turn it a certain number of clicks to split the dose? I should know how to do this....but if you can help me out I appreciate it! thank you 💝😊. ~36 clicks of the 2mg dose pen is 1mg. I split my 2mg dose in 1mg every 4 days.If you are on .25 then I would think metformen would be the way to go. Then I would talk to your dr about going down to .5 or even .25, maybe even a .25 every like 3.5 days if you don't mind jabbing yourself that much. Just make sure you get more needles if you start splitting. You are on Ozempic for T2D so decisions about doses must be made by ...We're 1 day old, be patient with us. This will be a great community soon! This is a safe place to discuss weight loss via Ozempic use. No medical reasons asked - but you can share if you want to and are respectful of others. Soon we'll have mods, fixed topics and flairs.When initiating Ozempic ®, consider reducing the dose of concomitantly administered insulin secretagogue (such as sulfonylureas) or insulin to reduce the risk of hypoglycemia. Ozempic ® causes a delay of gastric emptying and has the potential to impact the absorption of concomitantly administered oral medications, so caution should be exercised.The makers of Ozempic say their weight-loss drug Wegovy will be available to patients in Canada starting Monday. Novo Nordisk’s weekly injection is approved for …

In a 30-week, open-label trial (NCT02128932), 1089 patients with type 2 diabetes mellitus were randomized to OZEMPIC 0.5 mg once weekly, OZEMPIC 1 mg once weekly, or insulin glargine once daily on a background of metformin (48%) or metformin and sulfonylurea (51%). Patients had a mean age of 57 years and 53% were men.Interest in semaglutide, the generic name for Ozempic and Wegovy, spiked in 2023. Clinical trials indicated that, with these drugs, people can lose an average of 15% of their body weight. However ...The new 2mg dose of Ozempic will be supplied as 8mg/3mL (2.68mg/mL) of semaglutide in a single-patient-use pen delivering 4 doses of 2mg per injection. Previously, Ozempic was available as a ...It is not known if Ozempic® can be used in people who have had pancreatitis. Ozempic® is not for use in people with type 1 diabetes. It is not known if Ozempic® is safe and effective for use in children under 18 years of age. Important Safety Information Do not share your Ozempic® pen with other people, even if the needle has been changed ...In today’s digital age, PDF files have become an integral part of our personal and professional lives. However, there are times when we need to extract or split specific pages from...I worked my way up from 1/4 for the first week, then 1/4 for six days, etc. I am currently doing 1/3 of a 1 mg dose twice a week and plan to move up to 2/5 dose three times (weeks) and then to 1/2 dose twice a week. At this point, it would be the same as a weekly1 mg dose.

It is not known if Ozempic® can be used in people who have had pancreatitis. Ozempic® is not for use in people with type 1 diabetes. It is not known if Ozempic® is safe and effective for use in children under 18 years of age. Important Safety Information Do not share your Ozempic® pen with other people, even if the needle has been changed ...I would continue with the next split 0.5 dose. You just started the weekly 1.0 dose. I will take 4 weeks before it will have the maximum effect. This is because prior doses slowly break down and add to the current dose. Be patient. I started splitting at 0.75. 5 months in and currently at 1.3. Started losing at 0.75.I have a question about splitting doses. I have been stalled for about a month on 1.0mg. My doctor upped me to 2.0mg, but understandably I'm worried about having side effects. I WANT to split and take 1.0 and 1.0 but my doctor's nurse (grr) told me that it wasn't possible to split doses. Um, sure it is!! Is it worth splitting my very first dose? If so, how would I do it? I’m Type 2 diabetic FWIW. This is for diabetes primarily. I just stopped Metformin because it was making me super nauseous… but that went away when I stopped, and Ozempic stays in your system longer, so I’m totally freaked out. Also! What’s the best time of day to inject?

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University of Pittsburgh endocrinologist, Dr. Jason Ng, explained the mechanics: “Weight loss plateau happens when your body’s energy burn equals energy being added through food ..."The reductions in blood glucose seen with semaglutide 2 mg demonstrate that a higher dose of Ozempic ® may offer individuals the opportunity to further improve their diabetes control, with ...I am on week 7 and am on .50mg. I had some side effects on .25 and due to work obligations and travel, wanted to avoid any additional symptoms on the increase. I discovered splitting dose via Reddit and so far so good! My question is whether it’s recommended to keep splitting, or should you aim to transition over time to the full dose …Ozempic is a medication used to treat type 2 diabetes, but it may cause some side effects, ranging from common to severe. Learn more about the possible side effects of Ozempic, how to manage them, and when to seek medical attention. Compare Ozempic with other drugs and find out how to use it safely and effectively.The typical starting dose for Ozempic is 0.25 mg once a week. The maximum dose of Ozempic is 2 mg once a week. That means your dose may go up as many as 8 times. At first, you may need to increase your dose every week. Going up on your dose slowly may lower your risk of developing Ozempic-related nausea and other side effects.For those of you who used to have bad constipation on Ozempic, did splitting the dose: 1/2 dose for the first three days 1/2 dose for the next four days cure the constipation (safely), while still allowing you to feel full and lose weight? Thanks!

I’m just worried that I’m doing the dose splitting wrong somehow, and I know I can’t handle the side effects of doing even .5mg at once (at least at this point until maybe my body gets more used to it). Hopefully this all even makes sense. ... Hi, I made the site that helps you find Ozempic near you using AI callers. I made some ...Mounjaro and Ozempic have been studied in a head-to-head clinical trial. The trial compared three Mounjaro doses (5 mg, 10 mg, and 15 mg) to the 1 mg Ozempic dose over 40 weeks (about 9 months). People receiving any dose of Mounjaro had a greater reduction in hemoglobin A1C (HbA1C or A1C) compared to people receiving Ozempic. A1C is your ...Ozempic (Semaglutide) is a GLP-1 analog that exerts its effects primarily on the gut. Diarrhea, especially, immediately after eating, is one of the most common side effects of Ozempic as reported in different clinical trials. In clinical trials of a head-to-head comparison of short-acting and long-acting GLP-1 analogs, it was observed that ... I have a question about splitting doses. I have been stalled for about a month on 1.0mg. My doctor upped me to 2.0mg, but understandably I’m worried about having side effects. I WANT to split and take 1.0 and 1.0 but my doctor’s nurse (grr) told me that it wasn’t possible to split doses. Um, sure it is!! Mar 31, 2023 · Turn the dose selector until the dose counter shows the flow check symbol. Hold the pen with the needle pointing up, with your thumb on the bottom and the pen between your fingers. Press and hold the dose button until the dose counter shows zero. The number zero must line up with the dose pointer. It seems that for the 1mg dose pen, it goes 72 clicks as per this post here. That chart is slightly off for at least the 0.25 mg Ozempic pen, 0.25 mg dose is 19 clicks not 18, and for the 0.5 mg dose pen, 0.5 mg dose is 37 clicks not 36, so I would be sceptical of it beight right for the 1.0 mg pen either. I do, 1/2 Friday and 1/2 Tuesday. It helps limit side effects for me, and the thoughts of food stay away longer. I split my dose in half, I'm on 1 mg. I take half Monday, and half Thursday. The benefit is I don't spend the entire week barfing my brains out. I still get nausea, and some vomiting if I ignore the signs of the nausea and don't take ...Ozempic and Wegovy are both injections that contain semaglutide. Ozempic is approved to treat Type 2 diabetes. Wegovy is a higher-dose version that’s approved for weight loss. They aren’t interchangeable. Adults and adolescents ages 12 and older meeting certain body mass index (BMI) criteria may be eligible for Wegovy.

Accordingly, Ozempic clicks dosage is: 0.25 mg, 0.5 mg and 1 mg. However, you can adjust the dose more accurately using "clicks" (which are made by the selector notches on the syringe pen). So, there are 19 "clicks" between 0 mg and 0.25 mg in the first type of pen. And there are 18 "clicks" between 0.25 mg and 0.5 mg (37 in total).

I like the Ozempic system much better, where you can control the volume. I noticed that Wegovy also used an autoinjector like MJ. I’m guessing that both drug companies decided that they didn’t want patients buying the high doses and splitting them up to save money, so they made that pretty difficult.Problems with splitting dose. I tried splitting my dose as I saw that many people had success with this. I am on 1mg/week and although I was losing weight I had a lot of side effects that were getting frustrating. Unfortunately after several weeks of splitting doses, I found that although it did improve the side effects, that it also allowed my ...Split doses work to reduce nausea by better spreading the dose over the full week as compared to a single peak shot. ... This will be a great community soon! This is a safe place to discuss weight loss via Ozempic use. No medical reasons asked - but you can share if you want to and are respectful of others. Soon we’ll have mods, fixed topics ...Jul 27, 2022 · 0.25mg every week for 4 weeks. 0.5mg every week for 4 weeks. If additional blood sugar control is needed, increase to 1mg every week for 4 weeks. If additional blood sugar control is needed, increase to 2mg every week. Depending on the dose you are prescribed, you are going to need the appropriate Ozempic pen product (as I described above) as ... The Today Show has been a staple in American households for over six decades. With its engaging hosts, diverse content, and commitment to delivering up-to-the-minute news and enter...Ozempic (semaglutide) injection 0.5 mg, 1 mg, or 2 mg is an injectable prescription medicine used: along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes. to reduce the risk of major cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes with known heart disease.Meaning Im not sure your dr will be able to 'double' your prescription. That's why they made Wegovy. If you instead decrease the days between injections of 1mg Ozempic, you can up the dose in steps similarly to wegovy. 1mg every 5 days equals 1.4mg a week. 1mg every 4 days equals 1.75mg a week. 1mg every 3 days equals 2.33mg a week.Split dose question Question Scheduled to pick up my second pen, after the initial 6 week dose pen. It's going to be a 1 mg pen, but I feel like the first couple weeks I still want to be on .50 mg. Since I'm paying out of pocket, I might as well try and extend it out to 6 weeks anyway. ... One year difference and 7 months on Ozempic ...I'm on 1mg Ozempic and have a second prescription for 1mg Ozempic arriving. Pharmacists in the UK don't talk to each other and this is a way of me eventually getting to 2mg before Wegovy is available. ... I prefer to take it twice per week and split my dose. I'm on 0.5mg and will do 0.25mg one night, then 0.25mg again 3 nights later. It reduces ...Note that 14 mg daily is the maximum dose of Rybelsus, equivalent to 1 mg weekly of Ozempic. But a healthcare provider may prescribe up to 2 mg weekly for Ozempic. In studies, people taking Ozempic (2 mg weekly) experienced even more weight loss and A1c reduction than those taking Ozempic (1 mg weekly).

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Has. anyone had success with minimizing symptoms by splitting the dose? This is week 4 and I've spent the first 3 in bed all weekend exhausted. Last weekend the nausea, vomiting and diarrhea was violent. Took about .12 in my thigh tonight and plan to repeat Sunday night.Intended for maintenance treatment at the 1 mg dose. Each pen delivers 4 doses of the 1 mg strength and will last for one month. A carton that contains one prefilled pen with 8 mg / 3 mL of Ozempic. This pen delivers doses of 2 mg per injection. The carton also contains 4 NovoFine Plus needles. Intended for maintenance treatment at the 2 mg dose.What Are Ozempic Strengths. Ozempic comes in four different strength pens — 0.25 mg, 0.5 mg, 1 mg, and 2 mg. In most cases, patients will start on 0.25 mg per week, maintaining their dose at 0.5 mg. In cases where patients need more blood sugar support, the maximum dose is 2 mg.Do not split, crush, or chew tablets. 2.2 Recommended Dosage Start RYBELSUS with 3 mg once daily for 30 days. The 3 mg dosage is intended for treatment initiation ... There is no equivalent dose of RYBELSUS for OZEMPIC 1 mg. Reference ID: 5316448 . 3 DOSAGE FORMS AND STRENGTHS RYBELSUS tablets are available as: . . . )]. ) RYBELSUS. % % % *The research outcomes were reported after 40 weeks, with subjects taking the 1-mg dose experiencing a 1.9% decrease in HbA1C compared with 2.2% in those taking the 2-mg dose. In terms of weight loss, 28% of participants on semaglutide 2 mg experienced a weight loss of at least 10% compared with 23% of those on semaglutide …I did 4 weeks on 0.25, then 4 weeks on 0.5 and this week I went to 1.0. 0.5 didn’t have a strong appetite suppressant effect for me. Assuming 1.0 mg is effective, my plan is to stay on that dose as long as “it’s working.”. My doctor defines “working” as at least 1-2 lbs loss per week sustained over a 4 week period.Ozempic 1 mg/dose (2 mg/1.5 mL) subcutaneous pen injector. The photos shown are samples only. 1898 Medication name. Warning Uses How to use Side effects Precautions Drug interactions Overdose Notes Missed dose Storage Medical alert Important note. Information last revised March 2024.Ozempic; Wegovy; Descriptions. Semaglutide injection is used to treat type 2 diabetes. It is used together with diet and exercise to help control your blood sugar. This medicine is also used to lower the risk of heart attack, stroke, or death in patients with type 2 diabetes, obesity, and heart or blood vessel disease. ….

A reverse stock split, also known as a stock consolidation, stock merge, or share rollback, is when a company combines several existing shares into fewer (but higher-priced) shares...OZEMPIC® comes in the following dosage forms: OZEMPIC® is supplied as a clear and colourless solution for injection in a prefilled pen. - OZEMPIC® is available in a carton of 1 disposable, prefilled, multi- -dose pen delivering doses of 0.25 mg or 0.5 mg, including 6 NovoFine® Plus needles. This pack size is intended to be usedTomorrow is injection day and I'm tempted to try splitting my dose after hearing so many people talk about it here. It seems like a lot of people experience a more consistent/smoother week. ... I've always struggled holding off the weight and luckily Ozempic has helped!Mar 31, 2023 · Turn the dose selector until the dose counter shows the flow check symbol. Hold the pen with the needle pointing up, with your thumb on the bottom and the pen between your fingers. Press and hold the dose button until the dose counter shows zero. The number zero must line up with the dose pointer. Ozempic has a half-life of one week, so it will stay in your body for about five weeks. Trulicity's half-life is five days, so that it will stick around for about three and a half weeks. Therefore, as a measure of half-lives, Ozempic lasts longer in your body than Trulicity.Consult a doctor before splitting Ozempic doses for weight loss due to serious side effects and off-label use risks; professional guidance ensures safe, effective use. ... Dose splitting reflection from personal experiences shared online, including a case where splitting to 0.4 mg per injection effectively reduced hunger and facilitated weight ...A: Splitting the Ozempic dose involves taking half of the recommended dosage in the morning and the other half in the evening. This allows for a more consistent release of medication throughout the day and helps stabilize blood sugar levels.Yes, same here. But for me, I thought it had more of a psychological background. Definitely feel a lot less hungry on Ozempic, even on that last day before the shot (week 5, went up to 0.5 today, have been injecting in the thigh, so GI side effects are minimal). Don't let guilt bring you down!Obesity is a global health challenge with few pharmacologic options. Whether adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of 2.4 mg as an adjunct to lifestyle ...Oct 3, 2023 · A: Splitting the Ozempic dose involves taking half of the recommended dosage in the morning and the other half in the evening. This allows for a more consistent release of medication throughout the day and helps stabilize blood sugar levels. Splitting ozempic dose, Ozempic is a safe and effective medication when used as directed. Talk to your doctor about the potential risks and benefits of Ozempic before starting treatment. What doses of Ozempic are available? Ozempic is available as a 0.5 mg or 1 mg dose injection. The recommended dose of Ozempic is 0.5 mg or 1 mg once weekly., Dosing designed with you in mind. Wegovy ® comes in 5 different dose strengths, which are injected under the skin. The starting dose is 0.25 mg once a week, and you will gradually increase your dose every four weeks. Your health care provider can select either 1.7 mg or 2.4 mg for your maintenance dose., Splitting dosages. After two weeks on .25mg (been taking it on Mondays) I've noticed come Friday, I'm super hungry again all weekend. I'm due to increase my dose to .50 but I'm a bit nervous of the side effects with it. I'm wondering if just taking a 2nd dose of .25 on Thursdays instead might be a better move to curb weekend appetite?, Radio signals from an FM antenna can be split to go to more than one receiver with the use of a coaxial cable splitter. The FM radio spectrum, from 88 to 108MHz, falls between chan..., Basal insulin is usually initiated at a conservative dose of 10 units/day or 0.1-0.2 units/kg/day, then titrated thereafter over several weeks or months, based on patients' self-measured fasting plasma glucose, to achieve an individualized target (usually 80-130 mg/dL). Through a shared decision-making process, confirmation of appropriate ..., The manufacturer notes that individuals can be switched from Ozempic 0.5 mg to Rybelsus 7 mg or 14 mg. Additionally, those on Rybelsus 14 mg can also be switched to Ozempic. A transition dose is ..., The main way semaglutide is excreted from the body is via the urine and faces and 3% of the dose is left unchanged, which may alter the composition of the urine and change its smell. ... Ozempic slows your digestive system down so it takes longer for food and waste to travel through your body which can increase how much water is pulled out of ..., The most common adverse reactions, reported in ≥5% of patients treated with Ozempic ® are nausea, vomiting, diarrhea, abdominal pain, and constipation. Drug Interactions. When initiating Ozempic ®, consider reducing the dose of concomitantly administered insulin secretagogue (such as sulfonylureas) or insulin to reduce the risk of hypoglycemia., Dose Splitting, who does it? : r/Ozempic. r/Ozempic. • 2 yr. ago. diwioxl. Dose Splitting, who does it? I read on a post in the sub about splitting the ozempic dose to reduce …, Is anyone taking .14mg a day for a weekly 1mg dose? Does it still work at that low? ... Go to Ozempic r/Ozempic • by CaptHollyhock. View community ranking In the Top 5% of largest communities on Reddit. Dose Splitting . Is anyone taking .14mg a day for a weekly 1mg dose? Does it still work at that low? I want to try and get out of big swings…, Mounjaro and Ozempic have been studied in a head-to-head clinical trial. The trial compared three Mounjaro doses (5 mg, 10 mg, and 15 mg) to the 1 mg Ozempic dose over 40 weeks (about 9 months). People receiving any dose of Mounjaro had a greater reduction in hemoglobin A1C (HbA1C or A1C) compared to people receiving Ozempic. A1C is your ..., Experts share the truth about how much weight you can actually expect to lose on Ozempic, what side effects look like and more. ... taking a 2.4 mg dose of semaglutide plus lifestyle interventions ..., I'm at 1.0 and split doses. I don't get any nausea but would be very achy/sore the day after my weekly shot of 1.0. I'm losing weight a bit faster now that I'm splitting doses, even though I tend to do my shots 4 or 4.5 days apart instead of 3.5. The day or two of soreness was making me lazy., TikToker Isis Navarro Reyes was arrested on May 1 for allegedly selling misbranded weight loss drugs, such as Ozempic, which may have resulted in a life …, Ozempic is a medication used to treat type 2 diabetes and obesity. It is injected under the skin once a week, but where is the best body area to inject it? Find out the pros and cons of different injection sites, the myths and facts about nausea, and the tips to make the injection easier and more effective., Starting Dose. The recommended starting dosage of Semaglutide or Compounded Semaglutide is 0.25 mg weekly for the first month (5 units on the syringe).⁷ This amount is just meant to introduce the medication into your system so it can begin acclimation. It doesn't start regulating your blood sugar levels at this point.⁷., Learn how to administer the injection, the number of doses per pen, and the proper disposal procedure. By Karen Berger, Pharm.D. | Mar. 31, 2023. What is …, Wegovy side effects. Common Wegovy side effects may include nausea, vomiting, stomach pain, loss of appetite, diarrhea, constipation, upset stomach, heartburn, burping, gas, bloating, stomach flu symptoms, headache, dizziness, tiredness, runny nose or sore throat, and low blood sugar (in people with type 2 diabetes). Serious Wegovy side effects., I was supposed to take 1mg later today, but I think I will approach this differently and try 1mg every 4-5 days depending on how I’m feeling, and eventually build up to the 2mg every week ( splitting the dose still) thanks for listening, that’s the update, k thanks bye! I post these so I can refer back to my own posts and monitor my progress. , Typically, microdosing involves taking a fraction of the standard dose, such as 0.25 mg or 0.5 mg of Ozempic. Monitor Your Blood Sugar Levels : Regularly monitor your blood sugar levels while microdosing Ozempic. This will help you assess the effectiveness of the treatment and make any necessary adjustments to your dosage., Meaning Im not sure your dr will be able to 'double' your prescription. That's why they made Wegovy. If you instead decrease the days between injections of 1mg Ozempic, you can up the dose in steps similarly to wegovy. 1mg every 5 days equals 1.4mg a week. 1mg every 4 days equals 1.75mg a week. 1mg every 3 days equals 2.33mg a week., Blurred vision has been reported as a potential side effect of Ozempic use in females. Monitoring any significant changes in sight is key. Being aware of heart rate shifts is essential. Palpitations may happen after an injection but usually aren't serious concerns unless persistent or accompanied by other symptoms., Interest in semaglutide, the generic name for Ozempic and Wegovy, spiked in 2023. Clinical trials indicated that, with these drugs, people can lose an average of 15% of their body weight. However ..., The makers of Ozempic say their weight-loss drug Wegovy will be available to patients in Canada starting Monday. Novo Nordisk’s weekly injection is approved for …, Noooooooooo! You MUST titrate from lowest dose, or you will end up in the emergency room. Obviously the doc didn't read the prescribing information very well. Call an Ozempic rep at their help line or contact the pharmacist, who actually should have told you. Even the 0.25mg starting dose nearly messed me up good. Low and slow or not at all., • ®When initiating Ozempic , consider reducing the dose of concomitantly administered insulin secretagogue (such as sulfonylureas) or insulin to reduce the risk of hypoglycemia. • ®Ozempic causes a delay of gastric emptying and has the potential to impact the absorption of concomitantly administered oral medications, so caution should be ..., So for 0.5 mg it would be 36 clicks. Just Google Ozempic clicks 0.5 mg and you will get the answer :) I have been splitting doses for 5 months now, and I prefer it. You do need extra needles however. If you're on .5 and you want to split your dose you can do 18 clicks one day, and 3 days later do the other 18 clicks. So.25 twice a week., Ozempic ® should be administered by a patient once weekly on the same day each week, at any time of the day, with or without meals.. The day of weekly administration can be changed if necessary as long as the time between 2 doses is at least 2 days (>48 hours). If a patient misses a dose, they should administer Ozempic ® as soon as possible within 5 days after the missed dose., Novo Nordisk, the creator of Ozempic, provides the following guidelines: If you miss your regularly scheduled dose, take the missed dose as soon as possible within 5 days of the missed dose. You shouldn't take two doses of Ozempic within 48 hours of each other. If it's been more than 5 days since the missed dose, skip the missed dose ..., Ozempic ® should be administered by a patient once weekly on the same day each week, at any time of the day, with or without meals.. The day of weekly administration can be changed if necessary as long as the time between 2 doses is at least 2 days (>48 hours). If a patient misses a dose, they should administer Ozempic ® as soon as possible within …, In today’s fast-paced world, staying informed about local news is more important than ever. With the rise of digital media, online news platforms have become a popular choice for m..., Pen dose strength. Ozempic pens come in several different strengths that are written as milligrams of semaglutide (Ozempic's active drug) per milliliter of solution (mg/mL). Strength: Dose given per injection: 2 mg/1.5 mL (this may also be written as 1.34 mg/mL) 0.25 mg or 0.5 mg: 2 mg/3 mL (0.68 mg/mL), cleverfox2001. •. Yes, splitting works to reduce side effects by spreading the dose over the week. Half on day 1 and half on day 4. I've been doing it for the last 3 months with great success. You may need to do pen clicks to get the half dose of 1.0. Count the clicks to 2.0 and divide by 2. Click the pen to that setting.